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Because the medication works by the same mechanismslowing gastric emptying and affecting brain signalingthe gastrointestinal responses remain the primary side effects regardless of the manufacturer

They are not approved for weight loss or for use in people who do not have diabetes, although some clinicians have prescribed them offlabel for weight management in the past

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In kidney studies, Glp1r/ knockout mice experienced worse nephritis and diabetic kidney damage

January 2, 2026: Trulicity (Dulaglutide) May Be Safe for Use by Pregnant Women, Study Suggests Trulicity (dulaglutide) is used by many patients to control their diabetes