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Most of these studies have a combined predefined endpoint of the classical MACE-3 (major adverse cardiovascular endpoint) consisting of cardiovascular death, non-fatal myocardial infarct and non-fatal stroke

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3 independent experiments were analyzed in each condition ( b,e,h )

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PHQ-9 had reached 18moderately severe depressionand Hamilton Depression Rating Scale 17 items (HDRS-17) was 22, meeting DSM-5 criteria for a moderate-to-severe major depressive episode

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