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Tfr1 plays a pivotal role in regulating cellular iron overload and its elevated expression level substantiates this conclusion

Discuss the prohibited status of peptides under WADA, National Collegiate Athletic Association (NCAA), many professional sports, and potential sanctions

Assessment of brain activity The brain function was evaluated using NIRS

Additionally, cAMP/PKA signaling rapidly mobilizes GH-containing secretory granules and promotes their fusion with the plasma membrane, causing acute release of stored GH into the hypophyseal capillaries that drain into systemic circulation

Funding This work was supported by the National Science and Technology Major Project (2022ZD0117700), the National Natural Science Foundation of China (32270759) and the Research Foundation for Postdoctoral (AUGA5710026124)