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For example, ACC inhibitors are being explored for their potential to reduce lipogenesis and thus decrease fat accumulation in the liver and other tissues [12, 17, 19, 20]

doi: 10.1371/journal.pone.0161969

The most common side effects were mild to moderate gastrointestinal issues, such as nausea and diarrhea, which were more frequent with Tirzepatide

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Thus, regardless of our understanding of the physiology or pathophysiology of islet produced GLP-1, these data suggest that this pool of GLP-1 could be targeted to treat T2DM and avoid some of the CNS side-effects (i.e., nausea) associated with long-acting GLP-1 agonists