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doi:10.1007/s12178-025-09990-7

Together, these structural and computational methodologies form an iterative discovery loop in which experimentally derived viral conformational ensembles constrain AI-based predictions, while in silico analyses refine hypotheses on allosteric hotspots, receptor-blocking strategies, and conformational trapping mechanisms

The FDA also warns that topiramate may cause birth defects, like cleft lip and cleft palate

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These recent experimental findings are biologically plausible, particularly as both oxidative stress and neuroinflammation are increasingly recognized as important contributors to the pathophysiology of ASD (151, 156, 160)