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Reported side effects include skin rashes, abdominal pain (in rare instances), and temporary lightning in patches, which normalizes during treatment

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doi:10.1016/j.jamda.2016.09.010

Classic studies established that TLR activation upregulates VDR and CYP27B1, leading to the production of LL-37 and strengthening antimicrobial defense [240]

Our overarching framework is that gutbrain (and other periphery-to-brain) endocrine signaling may play a role in AUD (and potentially other substance use disorders) and could therefore represent novel targets for treatment development