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It uses a methyl group donated by S-adenosylmethionine (SAM) to methylate nicotinamide a vitamin B3 form that would otherwise be recycled back into NAD+

The Caenorhabditis elegans protein FIC-1 is an AMPylase that covalently modifies heat-shock 70 family proteins, translation elongation factors and histones

NAD+ and glutathione naturally decline with age , contributing to cellular dysfunction, oxidative stress, and increased risk of chronic diseases like Alzheimer's, Parkinson's, and metabolic disorders

It is naturally produced by your body in your glutathione pathway