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Malic enzyme 1 (ME1) is a potential oncogene in gastric cancer cells and is associated with poor survival of gastric cancer patients

Established benefits of B12 therapy: Treatment of documented deficiency: Intramuscular hydroxocobalamin is the standard NHS treatment for pernicious anaemia and other causes of B12 deficiency, effectively reversing haematological and neurological complications

Side Effects The somatostatin analogs can reduce the production of cholecystokinin (CCK), a small intestinal hormone that stimulates post-prandial (after a meal) gallbladder contraction

C.et al (2018)

The official recommendation is 10 mg of pantothenic acid per day and most physicians will be hesitant to recommend mega-doses of any vitamin- even water-soluble ones that are easily excreted in urine because they simply havent been studied extensively (Source)