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Protease inhibitors and reducing agents should be added to the buffers, as required, to minimize proteolysis of the fusion protein

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However, make sure to patch-test the formula test

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Prior to that, the company had committed $500M into an active pharmaceutical ingredient (API) plant in Ireland, $1.6B to expand its new manufacturing sites in Indiana, and $1.7B over three years for the expansion of their fill-finish sites at Research Triangle Park, NC and Concord, NC