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GLP-1R is expressed in multiple cardiovascular cell types such as monocyte/macrophages, smooth muscle cells, endothelial cells, and cardiomyocytes

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Subsequent dermal migration results in the establishment of a dermal component

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So if something goes wrong and the GSSG accumulates, it inhibits an enzyme that relies on the correct oxidation of the ER environment to operate a protein quality control system. Moreover, they discovered, when misfolded proteins dont pass quality control, they wont get exported, so they too pile up in the ER