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Pathologically, ALS is characterized by motor neuron degeneration and a constellation of co-occurring molecular abnormalities, including excitotoxicity, mitochondrial dysfunction, oxidative stress, necrosis, altered proteostasis, impaired cytoskeletal trafficking, DNA damage, and dysfunctional RNA metabolism

(1984) Opioid receptor reserve in normal and morphine-tolerant guinea pig ileum myenteric plexus