In 1938, scientists discovered carnosine as an important intracellular pH buffer in the muscle
However, the SUSTAIN six trial evaluated semaglutide, a GLP-1 analog, in patients with type 2 diabetes and high cardiovascular risk and discovered that semaglutide was associated with a higher incidence of diabetic retinopathy complications compared to placebo, with a hazard ratio (HR) of 1.76, particularly in patients with pre-existing DR (Vilsbll et al., 2018)
Sirotkin et al., 2020)
GH helps maintain a healthy lipid profile, potentially reducing bad cholesterol (LDL) levels and increasing good cholesterol (HDL)
Benefits Rapid and significant reduction in hot flash frequency and severity Additional benefits for sleep, vaginal dryness, and bone health Risks and Considerations Risks include blood clots, stroke, heart disease, and certain cancers, particularly with long-term use or in older women Best started within 10 years of menopause onset or before age 60 for optimal benefit-risk balance The lowest effective dose for the shortest duration is recommended If you decide to stop HRT, symptoms may return
