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The behavioral phenotype of PTZ-induced seizures was manually quantified from the recorded video analysis, using a standardized staged analysis model as shown in Table 1 (Mussulini et al., 2013)

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Regarding safety, mild to moderate gastrointestinal events were observed and one case of acute pancreatitis 21

J Biol Chem (2004) 279(22):2315865.10.1074/jbc.M314322200 202 SayinSIWahlstrmAFelinJJnttiSMarschallHUBambergKet alGut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist