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Methods Two sets of in silico experiments were performed using molecular docking simulations to determine the influence of hGH fragment 176191 peptide on the anticancer efficacy of doxorubicin 1) the binding affinities of hGH fragment 176191 peptide to the breast cancer receptors, 2) the effects of hGH fragment 176191 peptide binding on doxorubicin binding to these same receptors

It directly influences cardiac function through dual mechanisms: reducing sympathetic tone to decrease heart rate, and acting on cardiomyocytes via GPCRs to induce negative inotropic effects, manifesting as reduced contractility parameters (Poll et al., 2021)

No other competing interests were reported

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Allergic reactions: Symptoms of an allergic reaction include swelling of the face, lips, tongue, or throat