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Since semaglutide is a long-acting medication, it remains in your body for a significantly longer period than most medications

First Few Weeks: Adjustment Fatigue The first 2 to 4 weeks of starting semaglutide often bring noticeable fatigue

Other Uses: Oral mucosa healing, nerve regeneration, inflammatory modulation

Journal of molecular endocrinology

[15] [16] For weight management, FDA-approved agents include semaglutide 2.4 mg (Wegovy), tirzepatide (Zepbound), and liraglutide 3 mg (Saxenda), with weight reduction varying by medication (typically 5-15% with liraglutide, 15-20% with semaglutide, and up to 20-25% with tirzepatide)