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A deficiency of NAD+ may disrupt the circadian rhythm and result in effects such as daytime sleepiness, restless sleep, hormonal imbalances, and mood alterations, among others

doi: 10.1001/jamanetworkopen.2023.3005 7 LiuJJiXPittSWangGRovitELipmanTet al

Lipids are susceptible to oxidation and reacts with molecular oxygen to form lipid peroxyl radicals which further oxidizes the neighboring lipids and propagates the oxidative damage [3]

In PTSD mice models, trauma exposure increased tyrosine hydroxylase expression (the rate-limiting enzyme in catecholamine biosynthesis), elevating stress hormones epinephrine and norepinephrine in serum and colon, which upregulated claudin-2 expression, confirming gut barrier dysfunction (Yadav et al., 2023)

Researchers concluded that glutathione isnt doing anything directly to the immune system, but its allowing your body to hyperactivate the immune system