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In addition to fisetin and Q, other natural substances derived from plants also exhibit senolytic properties, such as piperlongumine (PL) and its analogues (56), or the curcumin analog EF24 (57)

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Results GH activates AgRP neurons to produce orexigenic responses To identify GH response neurons, C57BL/6 mice received intraperitoneal (i.p.) injection of either phosphate-buffered saline (PBS) or GH and their brains were processed to detect the phosphorylation of signal transducer and activator of transcription 5 (pSTAT5), a marker of GHR activation 11