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Abbreviations MSM: methyl sulphonyl methane Vit C: vitamin C GPx: glutathione peroxidise GST: glutathione transferase GR: glutathione reductase HO: heme oxygenase ROS: reactive oxygen species RNS: reactive nitrogen species NO: nitric oxide CO: carbon monoxide GSH: glutathione

Arthritis Rheum (2014) 60(12):372333

Leptin is considered to be a good predictor of growth hormone (GH) burst, cortisol, estradiol, and thyroid hormone levels and its receptor is widely distributed throughout the body suggesting a pivotal role in mediating the hormonal adaptation to chronic starvation

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Collaborative efforts of various practitioners is required to achieve realistic results