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Plasma cytokines profile in patients with Parkinsons disease associated with mutations in GBA gene

Jat, Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype

Even more impressively, intracellular glutathione inside peripheral blood mononuclear cells (PBMCsa critical type of immune cell) increased by an astounding 100%

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Mitochondrial abnormalities have also been associated with point mutations in Hsp70 chaperone that makes it aggregation prone, thereby, increasing iron and free-radical load 15,16,17