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Acute unfolding of a single protein immediately stimulates recruitment of ubiquitin protein ligase E3C (UBE3C) to 26S proteasomes
It acts as a master regulator of the hypothalamic-pituitary-gonadal (HPG) axis, influencing the release of key hormones such as luteinizing hormone and supporting natural testosterone and estrogen signaling
The researchers evaluated the patient-reported outcomes of over 150 different real-world treatments to determine which interventions provided the most significant relief
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A reporting summary for this Article is available as a Supplementary Information file
