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The group of Von Zastrow was the first to identify a protein, named GASP for GPCR associated sorting protein, which could actively target DOR to lysosome (Whistler et al., 2002)

Emergency Situations Call 911 : Patients should call 911 or seek emergency care immediately if palpitations are accompanied by chest pain or pressure, severe shortness of breath, dizziness or lightheadedness, syncope (fainting) or near-syncope, or profuse sweating

Obesity and overweight are defined as accumulation of excessive or abnormal fat leading to increased risk to health, which can be measured by using body mass index (BMI) as a baseline

The findings highlight that while quality medicines are essential, they often come at a higher cost or not available at the facility level, presenting challenges for health systems and women worldwide

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