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The legislation exempts small-molecule drugs from the negotiation list for four years after FDA approval but exempts biologics for 13 years, a difference that critics argue creates a structural incentive for manufacturers to develop biologic rather than small-molecule treatments, because biologics escape price negotiation pressure for longer [1]

doi: 10.1007/BF01675364

Providers can explain potential results, changes to diet, and how often check-ins or dose adjustments might be needed

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