Yes, GLP-1 medications should be discontinued before planned conception: at least 2 months before for semaglutide, at least 1 month for tirzepatide, and when pregnancy is recognized for other agents
Thats when the red flags went up
doi:10.7556/jaoa.2020.050 Pizzo A, Lagan AS, Barbaro L
Which is so important because I think like, I had a really good friend who, when this came out, she was like sending me the posts and like, [00:49:35] but this isn't like, she's in her forties and she's like, but I've gained so much weight and I'm lifting heavier than I ever have before
We differentiated these lines down a hepatic lineage and queried the methylation status of chromosome 11p15 by pyrosequencing on Day 0 (iPSC stage), Day 10 (hepatic progenitor stage), as well as on Days 15, 18, and 20 (hepatocyte stages) (Supplementary Fig