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Mitochondrial Dysfunction Reduced energy production at the cellular level, weakening overall body function

Jerome MS, Kuthethur R, Kabekkodu SP, Chakrabarty S (2022) Regulation of mitochondrial function by forkhead transcription factors

Key points: In the only head-to-head trial, Wegovy produced 15.8% weight loss compared with 6.4% for Saxenda over the same 68-week period Wegovy 7.2 mg (approved January 2026) produces even greater results at 20.7% average weight loss Real-world data from Second Nature shows 19.1% weight loss with semaglutide when combined with behavioural support Semaglutide participants were nearly three times more likely to achieve at least 10% weight loss than liraglutide participants Side effects and tolerability Both medications share a similar side-effect profile, predominantly affecting the gastrointestinal tract

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10.2337/dc15-1498 53 RosenC