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Al-Aly explained that the use of GLP-1s has soared in the last couple years while multiple studies have captured their far-reaching benefits, but [we] realized that no one has comprehensively investigated the effectiveness and risks of GLP-1 receptor agonists across all possible health outcomes. In the study, Al-Aly and colleagues mapped out associations between GLP-1s and 175 possible health outcomes by comparing a cohort of people with diabetes who used the treatments (n = 215,970) with: those who used sulfonylureas (n = 159,465)

Cleveland Clinic

However, SGLT2 inhibitors produced a greater reduction in HbA1c than sulfonylureas at 104 weeks perhaps due to the lack of durability of sulfonylurea therapy discussed earlier (141)

Why the lag