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Altered ligand binding and transcriptional regulation by mutations in the PML/RAR ligand-binding domain arising in retinoic-acid-resistant patients with acute promyelocytic leukemia
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Peroxynitrite, formed from the reaction of superoxide and NO, is a major trigger of DOX-induced apoptosis and necrosis in cardiac cells
Data are mean SD for 18 participants
In a placebo-controlled study of 70 -amyloid positive patients with either amnestic mild cognitive impairment (a precursor to AD) or mild AD, those receiving 600 mg/day of benfotiamine for 12 months experienced less cognitive decline compared to placebo, but the differences did not reach statistical significance (p=0.125
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