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This result was replicated in a similar but larger investigation ( N = 1,735) comparing all available GLP-1RAs versus non-GLP-1RA antidiabetics, with this antidepressant association possibly correlating with changes in markers of systemic inflammation (that is, high-sensitivity C-reactive protein) 192

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In addition, interaction with the intracellular G-protein for signal transduction appeared to be reliant on the GABA B R2 protomer, with ligand binding reliant on the GABA B R1 protomer (Margeta-Mitrovic et al., 2000