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Saraswat M, Musante L, Ravida A, Shortt B, Byrne B, Holthofer H

Sarkar et al., 2019)

Moreover, the heart increases lactate uptake and utilization via the TCA cycle and, mostly, lactate glycolytic production 84,85 , resulting in an increase in circulating lactate

Thus, the -glutamyl cycle may be considered as a multi-organ cycle in which the synthetic part occurs in liver and the catabolic part occurs in kidney amongst other tissues

Currently, ALRN-6924 is being studied in several clinical trials (Table 3)