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(This explains why hydroquinone has long been used for melasma removal , where brown or gray-brown patches of skin appear on foreheads, cheeks, chins and bridge of the nose.) In smaller doses (of at most 2%), hydroquinone can be purchased over-the-counter but pigment removal products with at least 4% hydroquinone concentration (considered to be the most effective concentration), require a prescription from a skin care specialist

Akiyoshi T, Ueda Y, Yanai K, Yamaguchi H, Kawamoto M, Toyoda K, Hayashi T, Ohuchida J

10.1016/j.cmet.2019.09.001 138

Stability references the time period during which a pH buffer's published accuracy can be met

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