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Other potential risk of the HGF/c-Met inhibition by the systemic treatment is in affecting the tissue regeneration and damage repair processes in patients, although we did not observe any side effects on our mouse models upon SU11274 administration

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Also, the proliferation assay revealed that GSTM3 overexpression in MIA PaCa-2 stable cell lines resulted in significantly abolished proliferation capacity compared to NC cells (Figure 3B)