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the broader metabolic case is being built through the CagriSema combination rather than cagrilintide alone
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1 Beyond the weight-loss stress response, researchers have proposed several contributing mechanisms: Hormonal shifts , changes in insulin and insulin-like growth factor (IGF-1) signaling during rapid weight loss, may influence androgen activity and accelerate androgenetic alopecia in genetically predisposed patients
Combining two metabolically active agents that influence body composition and hormonal signalling introduces a range of potential safety concerns, even when each drug is used individually within its intended parameters
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