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JZ: Writing review and editing

The abnormal signal pathways will lead to excessive production of FFAs and ROS in adipocytes and hepatocytes, which is a milestone of the first step to develop MASH (Portincasa et al., 2024)

The SURMOUNT-4 randomized clinical trial assessed the effect of tirzepatide discontinuation on the maintenance of weight reduction in adults with obesity and a weight-related complication, excluding diabetes

Rev Endocr Metab Disord 15 , 181187 (2014)

What that data shows is that while commercial hospital reimbursement rates did increase relative to Medicare rates between 2020 and 2022, the difference isnt huge