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Further incretin-based drug development For both GIP and GLP-1, positive effects were also observed on cardiovascular complications [23], indicating a therapeutic potential beyond the improvement of diabetes complications

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implications for threshold and meaningful change estimation Helen Doll 1 , Michael DeRosa 2 , Shruti Dave 2 , Alyssa Bamer 3 1 Clinical Outcomes Solutions, Folkestone, UK, 2 Clinical Outcomes Solutions, Chicago, Illinois, USA, 3 Clinical Outcomes Solutions, Tucson, Arizona, USA Journal of Patient-Reported Outcomes 2026 , 10(Suppl 1) :301.5 Aims Receiver operating characteristic (ROC) curve analysis is often used to estimate thresholds related to meaningful change or condition severity

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A pronounced overlap in transcriptional signatures between GLP-1MK-801 and each of GLP-1 and MK-801 was observed (Fig