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Medication interactions Here are some of the grapefruit and drug interactions of concern you might wish to discuss with your doctor, per the FDA: Anticoagulants/blood thinners (including warfarin) Antihistamines Anxiety medications Cholesterol-lowering statins Heart rhythm drugs High blood pressure medications Organ transplant drugs Some corticosteroids Talk to your doctor if you take any medications or supplements, or if you have any related underlying health conditions, before you consume grapefruit or grapefruit juice