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This dysfunction was associated with an impaired peroxisomal -oxidation, marked by increased levels of very long-chain fatty acids and the reduced expression of key genes involved in the -oxidation pathway such as ABCD1, ACOX1 and MFP2 (Nury et al., 2018)

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The cells treated with Sp showed slight enhancement in levels of GSH (~1.2 fold), together with minor alterations in GSSG levels, compared to untreated samples which exhibited higher GSSG content, thus indicating efficient recycling of GSSG to GSH (Fig

For instance, USM [H]L vesicles integrate encapsulated enzymes to degrade uric acid and hydrogen peroxide, generate photothermal effects for inflammation disruption, repolarize M1 macrophages to M2 phenotypes, and reprogram metabolic/immunological pathways for gout resolution (Yang et al., 2020)

During embryonic development, oligodendrocyte progenitor cells (OPCs) are specified from neuroepithelial neural stem cells in the spinal cord and the forebrain (Rowitch and Kriegstein, 2010)