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While cagrilintide primarily modulates appetite through amylin pathways, retatrutide engages multiple incretin and metabolic hormone systems simultaneously [8]

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Sensory information from the abdominal organs traverses the vagus nerve to the nucleus of the solitary tract in the brainstem, with projections to several other areas of the CNS, including the cerebral cortex and medulla oblongata (Liu and Forsythe, 2021)