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people with diabetes should seek supervised adjustment of these medicines to reduce hypoglycaemia risk Unexplained rapid heart rate or palpitations Injection site reactions that do not resolve For urgent concerns that are not emergencies , contact NHS 111 (online at 111.nhs.uk or by phone)
The motivations differ sharply by gender
their 53-year-old mother died after receiving illicit semaglutide injections at a beauty salon in May 2025
Seek immediate medical attention for: Severe, persistent abdominal pain, especially if different from typical IBS pain or radiating to the back (possible pancreatitis) Persistent vomiting preventing adequate fluid intake Signs of dehydration (decreased urination, dizziness, extreme thirst) Severe constipation lasting more than 3-4 days without bowel movement Blood in stool or black, tarry stools Yellowing of skin/eyes, right upper quadrant pain (possible gallbladder disease) Markedly reduced urination (possible acute kidney injury) Fever accompanying gastrointestinal symptoms Neck mass, difficulty swallowing, persistent hoarseness (thyroid concerns) Allergic reactions (rash, itching, swelling, severe dizziness) Scheduled follow-up should occur within 4-6 weeks of initiating therapy and after each dose escalation
