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Once inside the cell, the complex interacts with intracellular copper-responsive pathways which is what enables the downstream gene-modulation effects to translate from topical application into measurable dermal changes

HGF-Met pathway in regeneration and drug discovery

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As one of the most studied copper peptides in the scientific literature, GHK-Cu skin research has been particularly prolific, with numerous published studies exploring its role in extracellular matrix biology, collagen synthesis, and tissue remodeling processes

doi: 10.3390/ijms19071987