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Orforglipron is not yet approved as a weight loss treatment in the UK, as it is still undergoing clinical trials

SGLT2 inhibitors in patients with heart failure with reduced ejection fraction: a meta-analysis of the EMPEROR-Reduced and DAPA-HF trials

Now, I wouldnt do anything crazy like jump out of airplanes or get into a boxing ring, but most things are okay. Low-impact activities such as walking, biking, yoga, Pilates, and strength training should be fine