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First, the reproducibility of findings regarding gut microbiota diversity and its association with ASD symptoms is limited, often due to subject heterogeneity, small sample sizes, and inconsistent methodologies

doi: 10.3389/fphar.2022.969107 Received 14 June 2022 Accepted 12 September 2022 Published 03 October 2022 Volume 13 - 2022 Edited by Dan-Qian Chen, Northwest University, China Updates Copyright 2022 Chen, Ye, Wang, Liu, Wang, Wang, Xu and Gong

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However, large-scale multicenter trials such as ERICCA and RIPHeart have not demonstrated its ability to improve major outcomes like 30-day postoperative mortality