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From the microscopic standpoint, the majority of MPNSTs are hypercellular, high grade spindle cell sarcomas with plentiful mitoses, often with some degree of nuclear pleomorphism and/or necrosis, and variable positivity for S100, SOX10, EMA, CD34, Nestin, GFAP, collagen IV, and p53 by immunohistochemistry

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These findings have implications for dilated cardiomyopathy research, post-infarction remodeling studies, and investigations into preventing adverse cardiac remodeling that leads to chronic heart failure

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