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It describes microdose weight change as roughly zero to five pounds per month and highly variable, framing the approach as optimizing metabolic markers rather than producing dramatic reduction

139,140,141 Although dual agonists show advantages in efficacy, their safety and tolerability continue to be a focus of ongoing monitoring

They can degrade when exposed to heat, light, or enzymes, and they require protection to remain intact until they reach systemic circulation

Several studies have suggested that DPP-4 inhibitors and GLP-1 analogs are more effective treatments for pasireotide-induced hyperglycemia than metformin or insulin therapy 25,26

Int J Obes Relat Metab Disord 2002