Variability in toxicity between age groups may be accounted for by differences in metabolism, transport, and the genetics behind those differences
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This generally is not critical in testing male Caucasians, but it certainly is a problem in diagnosing some Caucasian females and blacks of both sexes, especially during the reticulocytosis following acute hemolysis
However, if a specialized laboratory test is used, stable metabolites of the peptide can typically be detected for roughly 24 to 48 hours after administration, with some studies suggesting trace detection up to 4 days later