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GLP-1R activity also promotes the transactivation of epidermal growth factor receptor (EGFR), which then signals through phosphoinositide 3-kinase (PI3K) and insulin receptor substrate-2 (IRS-2), and subsequently activates extracellular-signal-regulated kinase 1 and 2 (ERK1/2) and nuclear translocation of PKC to mediate -cell proliferation and differentiation (114)

GLP-1RA use is associated with health benefits, including weight loss and reduced MACE risk

The general profile in trials is gastrointestinal side effects and dose-dependent heart-rate increases

Importantly it was not until millions of women had taken the pill over a period of time that researchers began to understand the true nature of their benefits and side effects

For diabetes patients, counseling often focuses on glycemic monitoring, integration with other medications, and recognition of hypoglycemia risk in combination therapies