Pediatric patients with BBS, POMC, PCSK1, or LEPR deficiency treated with IMCIVREE had greater incidences of vomiting, skin hyperpigmentation, and new or darkening nevi compared to adults with BBS, POMC, PCSK1, or LEPR deficiency treated with IMCIVREE [see Adverse Reactions(6.1)]
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These therapies can help reduce stress, improve immune function, enhance muscular function, drive brain body control, and promote overall physical and emotional health
Phase 2 trials have shown modest reductions in systolic blood pressure of approximately 46 mmHg in higher-dose groups, most likely driven by significant weight loss