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Semaglutide is not recommended for those with a history of thyroid cancer, type-1 diabetes, history of pancreatitis, people who are pregnant, or in on other blood sugar lowering medications

Key objectives include determining long-term safety, identifying patient subgroups most likely to benefit, clarifying effects across HF phenotypes, and assessing patient-centered outcomes such as quality of life, functional status, and hospitalization burden

Semaglutide has a seven-day active window, meaning one weekly injection provides continuous GLP-1 signaling throughout the week

Longer-term effects should be investigated further (101)