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Experts are specifically concerned about the following issues: The U.S

While no head-to-head trials have compared GLP-1 drugs specifically for migraine outcomes, we can draw some inferences from their pharmacological profiles and side effect data

Our CLP model showed chronic Nrf2/HO-1/GPX4 suppression (day 7) linked to GSH depletion, ferroptosis, and irreversible antioxidant collapse (Xie et al., 2020), supporting Nrf2 activators (e.g., sulforaphane) or GSH precursors (e.g., NAC) as interventions (Yusri et al., 2025)

Mehandru S, Colombel JF

(2021), reported that DNA methylation changes in different genomic regions of CI-related genes are associated with their transcript levels