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Interestingly, it has been found that bronchoalveolar lavage fluid (fluid used to wash the lungs) contains higher concentrations of GLP-1 than blood, indicating that GLP-1 plays an important role in the lungs (5)

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Given that only one of eight large, randomized trials has demonstrated an increased risk of amputations it is unlikely that SGLT2 inhibitors significantly increase the risk of amputations