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Hundreds of studies have linked small changes in weight to big benefits: Lower blood pressure: Reducing BMI by just 2.27 pointse.g., going from a BMI of 26 to a BMI of 23.7, or losing about 20 poundscan lower systolic and diastolic blood pressure by 5.79 mmHg and 3.36 mmHg, respectively

2023;13(1):e1170

As such, what could have caused the weakening of the epithelial barrier in recent decades

Resveratrol protects primary rat hepatocytes against oxidative stress damage: Activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes

Collectively, these diverse epigenetic modifications orchestrate complex gene expression changes that governs astrocyte state transition