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4-HNE also has a signaling function and is involved in the regulation of several transcription factors sensitive to OS, such as nuclear factor erythroid 2-related factor 2 (Nrf2), activating protein-1 (AP-1), NF-B, and peroxisome proliferator-activated receptors (PPARs) [8]

Because cancer cells have significantly elevated glutathione (GSH) levels and a highly reducing intracellular environment, GSH serves as an effective trigger for selective activation of nanocarriers

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